Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse.
Yasufumi NagataPhilippe B BertrandVinit BaliyanJonathan KochavRuth D KaganKristian UjkaHassan AlfraidiAntonia van KampenJordan E MorningstarJacob P Dal-BiancoSerguei MelnitchoukGodtfred HolmvangMichael A BorgerReece MooreLanqi HuaRazia SultanaPablo Villar CalleBrian YumJ Luis GuerreroTomas G NeilanMichael H PicardJiwon KimFrancesca N DellingJudy W HungRussell A NorrisJonathan W WeinsaftRobert A LevinePublished in: Circulation. Cardiovascular imaging (2023)
Basal inferior-posterior myocardial fibrosis in MVP is associated with abnormal MVP-related myocardial mechanics, which are potentially associated with ventricular arrhythmia. These associations suggest pathophysiological links between MVP-related mechanical abnormalities and myocardial fibrosis, which also may relate to ventricular arrhythmia and offer potential imaging markers of increased arrhythmic risk.