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Enantioselective cellular localisation of europium(iii) coordination complexes.

Andrew T FrawleyHolly V LinfordMatthieu StarckRobert PalDavid Parker
Published in: Chemical science (2017)
The selective mitochondrial localisation of the Λ enantiomer of three different emissive europium(iii) complexes in NIH 3T3 and MCF7 cells contrasts with the behaviour of the Δ enantiomer, for which a predominant lysosomal localisation was observed by confocal microscopy. In each case, cell uptake occurs via macropinocytosis.
Keyphrases
  • induced apoptosis
  • oxidative stress
  • cell cycle arrest
  • single cell
  • cell therapy
  • breast cancer cells
  • mesenchymal stem cells