Antimicrobial bisabolane-type sesquiterpenoids from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330.
Xiao-Dong LiXin LiXiao-Ming LiXiu-Li YinBin-Gui WangPublished in: Natural product research (2019)
One new aromatic bisabolene-type sesquiterpenoid (1), along with four known analogues (2-5) were isolated and identified from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330. Their structures were elucidated by NMR, HRESIMS, X-ray crystallographic analysis, and quantum chemical ECD calculations as well as comparison of those data with literature data. Compounds 1-5 were evaluated for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1, 2 and 5 exhibited selective inhibitory activities against zoonotic pathogenic bacteria such as Aeromonas hydrophilia, Escherichia coli, Edwardsiella tarda and Vibrio harveyi, with the MIC values ranging from 1.0 to 8.0 μg/mL.
Keyphrases
- high resolution
- escherichia coli
- heavy metals
- staphylococcus aureus
- electronic health record
- molecular dynamics
- endothelial cells
- risk assessment
- big data
- systematic review
- biofilm formation
- magnetic resonance
- density functional theory
- molecular docking
- induced pluripotent stem cells
- amino acid
- magnetic resonance imaging
- machine learning
- multidrug resistant
- artificial intelligence
- candida albicans
- contrast enhanced
- energy transfer