Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease.
Zachary M SellersBeate IllekMiriam Frankenthal FigueiraGopika HariNam Soo JooEric SibleyJackson Souza-MenezesMarcelo M MoralesHorst FischerJeffrey J WinePublished in: PloS one (2017)
PGE2 stimulates bronchotracheal MCC and this response is decreased in CF. In CF airway, PGE2-stimulated Cl- and HCO3- conductance is impaired and may contribute to decreased MCC. There remains a CFTR-independent Cl- current in submucosal glands, which if exploited, could represent a means of improving airway Cl- secretion and MCC in CF.