Metabolic programming in the offspring after gestational overfeeding in the mother: toward neonatal rescuing with metformin in a swine model.

Sílvia Xargay-TorrentBerta Mas-ParésGemma Carreras-BadosaEsther Lizárraga-MollinedoJoan TibauJosep ReixachEstíbaliz Platero-GutierrezAnna Prats-Puig Francis De ZegherLourdes IbáñezJudit BassolsAbel López-Bermejo

Published in: International journal of obesity (2005) (2022)

Maternal overfeeding during gestation leads to metabolic abnormalities in the offspring, including adipose tissue alterations. Early metformin treatment mitigates these effects and could help rescue the offspring's metabolic health.

Keyphrases

high fat diet
adipose tissue
healthcare
public health
birth weight
pregnant women
insulin resistance
weight gain
mental health
preterm infants
pregnancy outcomes
gestational age
metabolic syndrome
radiation induced
combination therapy