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Biology and genetics of extranodal mature T-cell and NKcell lymphomas and lymphoproliferative disorders.

Natasha E LewisTing ZhouAhmet Dogan
Published in: Haematologica (2023)
The extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders represent a unique group of rare neoplasms with both overlapping and distinct clinicopathological, biological, and genomic features. Their predilection for specific sites, such as the gastrointestinal tract, aerodigestive tract, liver, spleen, and skin/soft tissues, underlies their classification. Recent genomic advances have furthered our understanding of the biology and pathogenesis of these diseases, which is critical for accurate diagnosis, prognostic assessment, and therapeutic decision-making. Here we review clinical, pathological, genomic, and biological features of the following extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders: primary intestinal T-cell and NK-cell neoplasms, hepatosplenic T-cell lymphoma, extranodal NK/T-cell lymphoma, nasal type, and subcutaneous panniculitis-like T-cell lymphoma.
Keyphrases
  • nk cells
  • epstein barr virus
  • copy number
  • decision making
  • machine learning
  • gene expression
  • deep learning
  • high resolution
  • diffuse large b cell lymphoma