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COVID-19 vaccinations: The unknowns, challenges, and hopes.

Kawthar MohamedPiotr RzymskiMd Shahidul IslamRangarirai MakukuAyesha MushtaqAmjad KhanMariya IvanovskaSara A MakkaFareeda HashemLeander MarquezOrsolya CseprekalIgor Salerno FilgueirasDennyson Leandro M FonsecaEssouma MickaelIrene LingAmanuel Godana AreroSarah CuschieriKseniia MinakovaEduardo Rodríguez-RománSunny O AbarikwuAttig-Bahar FatenGiulia GranciniOtavio Cabral-MarquesNima Rezaei
Published in: Journal of medical virology (2021)
The entire world has been suffering from the coronavirus disease 2019 (COVID-19) pandemic since March 11, 2020. More than a year later, the COVID-19 vaccination brought hope to control this viral pandemic. Here, we review the unknowns of the COVID-19 vaccination, such as its longevity, asymptomatic spread, long-term side effects, and its efficacy on immunocompromised patients. In addition, we discuss challenges associated with the COVID-19 vaccination, such as the global access and distribution of vaccine doses, adherence to hygiene guidelines after vaccination, the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, and vaccine resistance. Despite all these challenges and the fact that the end of the COVID-19 pandemic is still unclear, vaccines have brought great hope for the world, with several reports indicating a significant decline in the risk of COVID19-related infection and hospitalizations.
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