Symptom burden and its associations with clinical characteristics in patients with COPD: a clustering approach.

Sarah Houben-Wilke Qichen Deng Daisy J A Janssen Nienke Nakken Frits M E Franssen Martijn A. Spruit

Published in: ERJ open research (2024)

People with COPD report a high burden of respiratory as well as non-respiratory symptoms. Cluster analysis demonstrated a co-occurrence of different levels of symptom severity, highlighting the heterogeneity of symptoms experience. Identifying clusters of patients with shared symptom experiences will help us to understand the impact of the disease and define integrated, multidimensional treatment strategies.

Keyphrases

chronic obstructive pulmonary disease
lung function
single cell
patient reported
mental health
sleep quality
risk factors
respiratory tract
rna seq
cystic fibrosis
depressive symptoms
psychometric properties