Rho-Kinase inhibition decreases focal cerebral ischemia-induced glial activation in rats.
Abdullah Md SheikhShozo YanoShingo MitakiShatera TabassumShuhei YamaguchiAtsushi NagaiPublished in: Journal of central nervous system disease (2022)
Our study demonstrates the inhibitory effects of Rho-kinase on NF-κB-mediated glial activation and cerebral edema, which might be a promising therapeutic target in acute cerebral ischemia conditions.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- protein kinase
- brain injury
- blood brain barrier
- drug induced
- neuropathic pain
- liver failure
- signaling pathway
- tyrosine kinase
- high glucose
- diabetic rats
- oxidative stress
- smooth muscle
- respiratory failure
- pi k akt
- intensive care unit
- nuclear factor
- cell proliferation
- inflammatory response
- acute respiratory distress syndrome
- cerebral blood flow