Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Katie C CoateChunhua DaiAjay SinghJade E StanleyBrittney A CovingtonAmber M BradleyFavour OladipupoYulong GongScott WisniewskiErick SpearsGreg PoffenbergerAlexandria BustabadTyler RodgersNandita DeyLeonard D ShultzDale L GreinerHai YanSimeon I TaylorWenbiao ChenE Danielle DeanPublished in: bioRxiv : the preprint server for biology (2024)
Our findings demonstrate that interruption of glucagon signaling augments islet non-alpha cell proliferation in zebrafish, rodents, and transplanted human islets in a manner requiring SLC7A2 and mTORC1 activation. An increase in delta cell mass may be leveraged for future beta cell regeneration therapies relying upon delta cell reprogramming.