Carnosine selectively inhibits migration of IDH-wildtype glioblastoma cells in a co-culture model with fibroblasts.

Henry OppermannJohannes DietterleKatharina PurczMarkus MorawskiChristian EisenlöffelWolf MüllerJürgen MeixensbergerFrank Gaunitz

Published in: Cancer cell international (2018)

Our results demonstrate that the anti-proliferative effect of carnosine is not accompanied by an induction of cell migration. Instead, the dipeptide is able to prevent colony formation and selectively eliminates tumor cells in a co-culture with fibroblasts.

Keyphrases

cell migration
induced apoptosis
extracellular matrix
cell cycle arrest
low grade
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell proliferation