Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of Escherichia coli and Klebsiella pneumoniae in Two Kenyan Facilities: A National Referral and a Level Five Hospital.
Sylvia M MavekeGabriel Oluga AbogeLaetitia W KanjaAlfred O MaingaNaftaly GachauBeatrice W MuchiraGervason Apiri MoriasiPublished in: International journal of microbiology (2024)
isolates increases the utilization of last-resort antibiotics, jeopardizing antimicrobial chemotherapy. Furthermore, the antimicrobial resistance patterns exhibited towards extended-spectrum cephalosporins, beta-lactam/beta-lactamase inhibitor combinations, fluoroquinolones, and macrolides show the risk of co-resistance associated with ESBL-producing isolates responsible for MDR. Hence, there is a need for regular surveillance and implementation of infection prevention and control strategies and antimicrobial stewardship programs.
Keyphrases
- klebsiella pneumoniae
- escherichia coli
- multidrug resistant
- antimicrobial resistance
- gram negative
- public health
- primary care
- healthcare
- quality improvement
- genetic diversity
- staphylococcus aureus
- biofilm formation
- radiation therapy
- pseudomonas aeruginosa
- squamous cell carcinoma
- cystic fibrosis
- adverse drug
- rectal cancer
- electronic health record
- candida albicans