Pro- and anti-inflammatory cytokines mediate the progression of severe anemia in malaria-infected children: A prospective study.
Charles NkansahFelix Osei-BoakyeGabriel AbbamSamuel K AppiahSamira DaudBright BoakyeSamsiyatu AbdulaiMadina AhmedTheophilus B AntwiBirago BoatengMiigbat P LibatinAlexander S MensahMary K MissahRichard V DuneehAshiya HarunaStephany AddaPagnaa G Abdul-RaufZacharia A OforiGeorge B FosuSandra SegnitomeIsaac AdjeiEmmanuel Appiah-KubiMoses BanyehCharles A DerigubahMuniru M TankoEjike F ChukwurahPublished in: Immunity, inflammation and disease (2024)
Parasite density was the principal predictor of the cytokine levels, as parasitemia positively associated with IL-10, GM-CSF, IL-6, IL-1β, IFN-ɣ, and TNF-α, but negatively associated with IL-3 and TGF-β. Malaria is associated with enhanced secretion of pro- and anti-inflammatory cytokines in Ghanaian children. Inflammatory cytokines may be involved in the development of severe malarial anemia in children. However, IL-3 and TGF-β may offer protection against severe malarial anemia.