Association between rs2275913 single-nucleotide polymorphism of the interleukin-17A gene and perioperative analgesic use in cosmetic orthognathic surgery.

Seii OhkaDaisuke NishizawaJunko HasegawaKaori TakahashiKyoko NakayamaYuko EbataKen-Ichi FukudaAnd Kazutaka Ikeda

Published in: Neuropsychopharmacology reports (2018)

Opioid requirements during and after surgery are enhanced in carriers of the AA genotype of the rs2275913 SNP of the IL-17A gene, possibly through an enhancement of IL-17A function that induces inflammation that is related to the inflammatory pain stimulus.

Keyphrases

genome wide
chronic pain
pain management
oxidative stress
copy number
neuropathic pain
minimally invasive
genome wide identification
cardiac surgery
patients undergoing
transcription factor
acute coronary syndrome
atrial fibrillation