Multi-institutional study of the frequency, genomic landscape and outcome of IDH-mutant glioma in paediatrics.

Kee Kiat Yeo Sanda AlexandrescuJennifer A CotterJayne VogelzangVarun BhaveMarilyn M LiJianling JiJamal K BenhamidaMarc K RosenblumTejus A BaleNancy BouvierKristiyana KanevaTom RosenbergMary-Jane Lim FatHia GhoshMigdalia MartinezDolly AguileraAmy SmithStewart GoldmanEli L DiamondIgor GavrilovicTobey J MacDonaldMatthew D WoodKellie J NazemiAi Lien TruongAndrew ClusterKeith L LigonKristina ColeWenya Linda BiAshley S MargolMatthias A KarajannisKaren D Wright

Published in: Neuro-oncology (2022)

A subset of pediatric gliomas are driven by IDH1/2 mutations, with a higher rate among adolescents. The majority of patients underwent upfront observant management without adjuvant therapy. Findings suggest that the natural history of pediatric IDH1/2-mutant glioma may be similar to that of adults, though additional studies are needed.

Keyphrases

wild type
low grade
end stage renal disease
high grade
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
gene expression
patient reported
childhood cancer
genome wide