Login / Signup

Severe methotrexate toxicity in elderly patients under diuretics.

Cara KumarMatthias KuhnKristine HerrmannNicolai LeuchtenMartin Aringer
Published in: RMD open (2024)
Patients older than 70 years with lower eGFR and being on diuretics, but also on PPIs and levetiracetam, have a significantly higher risk for MTX toxicity.
Keyphrases
  • end stage renal disease
  • small cell lung cancer
  • ejection fraction
  • oxidative stress
  • chronic kidney disease
  • prognostic factors
  • physical activity
  • high dose
  • tyrosine kinase
  • low dose
  • patient reported