Oxidative Balance and Inflammation in Hemodialysis Patients: Biomarkers of Cardiovascular Risk?
Daniele La RussaDaniela PellegrinoAlberto MontesantoPaolo GigliottiAnna PerriAntonella La RussaRenzo BonofiglioPublished in: Oxidative medicine and cellular longevity (2019)
During chronic kidney disease, the progressive deterioration of renal function induces several biological/clinical dysfunctions, including enhancement of synthesis of inflammation/oxidative stress mediators. Impaired renal function is an independent cardiovascular risk factor; indeed, cardiovascular complications dominate the landscape of both chronic kidney disease and end-stage renal disease. The aim of this study is to explore the correlation between the global oxidative balance in hemodialysis patients and both inflammatory markers and cardiovascular events. Using photometric tests, this study explored plasmatic oxidative balance in 97 hemodialysis patients compared to a healthy population. In the hemodialysis patients, we showed that oxidative stress values were significantly lower than in controls while effectiveness in the antioxidant barrier was significantly increased in the hemodialysis group. Furthermore, we highlighted a strong correlation between oxidative index and blood levels of C-reactive protein. When patients were divided into two groups based on previous cardiovascular events, we found that subjects with previous cardiovascular events had higher values of both oxidative stress and antioxidant barrier than patients without cardiovascular events. Our results indicated that in hemodialysis patients, the clinical and prognostic significance of oxidative status is very different from general population. As cardiovascular complications represent a strong negative factor for survival of hemodialysis patients, the research of new cardiovascular risk biomarkers in these patients takes on particular importance in order to translate them into clinical practice/primary care.
Keyphrases
- end stage renal disease
- chronic kidney disease
- cardiovascular events
- oxidative stress
- peritoneal dialysis
- coronary artery disease
- cardiovascular disease
- primary care
- newly diagnosed
- ejection fraction
- dna damage
- clinical practice
- signaling pathway
- multiple sclerosis
- ischemia reperfusion injury
- anti inflammatory
- diabetic rats
- simultaneous determination