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PNPLA3 p.I148M and TM6SF2 p.E167K variants do not predispose to liver injury in cholestatic liver diseases: A prospective analysis of 178 patients with PSC.

Beata KrukRoman LiebeMałgorzata MilkiewiczEwa WunschJoanna Raszeja-WyszomirskaFrank LammertPiotr MilkiewiczMarcin Krawczyk
Published in: PloS one (2018)
Neither PNPLA3 nor TM6SF2 polymorphisms seem to contribute significantly towards an increased risk for deterioration of liver function in patients with PSC. These results underscore the divergent mechanisms of liver damage in cholestatic conditions as compared to metabolic and viral liver diseases.
Keyphrases
  • liver injury
  • drug induced
  • oxidative stress
  • gene expression
  • liver fibrosis
  • dna methylation