Adeno-associated virus 2 mediated gene transfer of vascular endothelial growth factor Trap: a new treatment option for glioma.

Shengnan ZhaoYakun ZhangLei WangLi YangLiqun ZouFabao Gao

Published in: Cancer biology & therapy (2018)

AAV2-VEGF-Trap has an obvious anti-angiogenic effect and inhibits the growth of glioma just by a single intravenous injection, which is similar to BEV. Moreover, there is a synergistic antitumor effect between AAV2-VEGF-Trap and TMZ.

Keyphrases

vascular endothelial growth factor
endothelial cells
gene therapy
copy number
genome wide
high dose
gene expression
drug delivery
low dose
ultrasound guided
dna methylation
transcription factor
smoking cessation
combination therapy
electron transfer