Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.

In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl- N -phenyl-1H-pyrazole-3-carboxamide ( L 1 ) and 1,5-dimethyl- N -propyl-1H-pyrazole-3-carboxamide ( L 2 ), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni( L 1 ) 2 ](ClO 4 ) 2 ( C 1 ) and a dinuclear complex [Cd 2 ( L 2 ) 2 ]Cl 4 ( C 2 ). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, L 1 and L 2 present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes C 1 and C 2 .