Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis.
Robert D GrayGareth HardistyKate H ReganMaeve SmithCalum T RobbRodger DuffinAnnie MackellarJennifer M FeltonLily PaemkaBrian N McCullaghChristopher D LucasDavid A DorwardEdward F McKoneGordon CookeSeamas C DonnellyPradeep K SinghDavid A StoltzChristopher HaslettPaul B McCrayMoira K B WhyteAdriano G RossiDonald J DavidsonPublished in: Thorax (2017)
CF neutrophils have a prosurvival phenotype that is associated with an absence of CFTR function and allows increased NET production, which can in turn induce inflammation. Augmenting neutrophil apoptosis in CF may allow more appropriate neutrophil disposal, decreasing NET formation and thus inflammation.