Fluorescence-guided surgery for high-grade gliomas.
Nikita LakomkinConstantinos G HadjipanayisPublished in: Journal of surgical oncology (2018)
5-aminolevulinic acid (5-ALA) is a prodrug that results in the fluorescence of high-grade gliomas relative to the surrounding brain parenchyma. 5-ALA has been increasingly utilized in fluorescence-guided surgery for these tumors, and its intraoperative use has been associated with a significantly improved extent of resection and progression-free survival. This review outlines the growing body of evidence that has culminated in the recent Food and Drug Administration approval of 5-ALA, as well as emerging applications for this agent.
Keyphrases
- high grade
- drug administration
- low grade
- free survival
- minimally invasive
- single molecule
- coronary artery bypass
- energy transfer
- surgical site infection
- photodynamic therapy
- white matter
- cancer therapy
- coronary artery disease
- patients undergoing
- percutaneous coronary intervention
- risk assessment
- multiple sclerosis
- atrial fibrillation
- drug release
- drug delivery
- climate change
- acute coronary syndrome