Mechanisms of Intravascular Linear Ablation Induced Restenosis in Rabbit Abdominal Aorta.
Qiang ChenManman WangShuai ShaoHongze LiuXiaodong XiaGary TseMeng YuanYue ZhangXue LiangTong LiuGuangping LiPublished in: BioMed research international (2018)
RBA can depress the intimal hyperplasia and promote dilatation of the artery to greater extents than PTA at 28 days. However, this did not involve TLR-4 signaling pathway, which likely plays a negligible role in mediating restenosis. Reduction of intimal hyperplasia may be due to injury of ablation to the tunica media and inhibition of VSMC proliferation and migration.
Keyphrases
- signaling pathway
- radiofrequency ablation
- high glucose
- toll like receptor
- inflammatory response
- coronary artery
- pulmonary artery
- pi k akt
- diabetic rats
- immune response
- catheter ablation
- aortic valve
- epithelial mesenchymal transition
- drug induced
- oxidative stress
- induced apoptosis
- endothelial cells
- pulmonary hypertension
- cell proliferation
- pulmonary arterial hypertension
- neural network