The Effect of KSK-94, a Dual Histamine H 3 and Sigma-2 Receptor Ligand, on Adipose Tissue in a Rat Model of Developing Obesity.

Magdalena KotańskaMonika ZadrożnaMonika KubackaKamil MikaKatarzyna SzczepańskaBarbara NowakAlessio AlesciAnthea MillerEugenia Rita LaurianoKatarzyna Kieć-Kononowicz

Published in: Pharmaceuticals (Basel, Switzerland) (2024)

receptor and, to a lesser extent, sigma-2 receptor, could be attractive therapeutic options for patients at risk of developing obesity or with obesity and some metabolic disorders. However, more studies are required to determine its safety profile and the exact mechanism of action of KSK-94.

Keyphrases

insulin resistance
adipose tissue
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
high fat diet
skeletal muscle
binding protein