Meropenem concentrations in brain tissue of neurointensive care patients exceed CSF levels.
Arthur HosmannLavinia RitscherHeinz BurgmannValentin Al JalaliBeatrix WulkersdorferMichael Wölfl-DuchekMaria Sanz-CodinaWalter JägerStefan PoschnerWalter PlöchlAndrea ReinprechtKarl RösslerAndreas GruberMarkus ZeitlingerPublished in: The Journal of antimicrobial chemotherapy (2021)
Meropenem achieves sufficient bactericidal concentrations for the most common bacterial strains of cerebral infections in both plasma and brain tissue, even in non-inflamed brain tissue. CSF concentrations would highly underestimate the target site activity of meropenem beyond the blood-brain barrier.
Keyphrases
- resting state
- white matter
- cerebral ischemia
- end stage renal disease
- healthcare
- functional connectivity
- ejection fraction
- newly diagnosed
- gram negative
- escherichia coli
- peritoneal dialysis
- subarachnoid hemorrhage
- palliative care
- prognostic factors
- multiple sclerosis
- brain injury
- blood brain barrier
- chronic pain
- cerebrospinal fluid