Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.

Fabyan Esberard de Lima Beltrão Daniele Carvalhal de Almeida Beltrão Giulia Carvalhal Fabricia Elizabeth de Lima Beltrão Jair de Souza Braga Filho Jocyel de Brito Oliveira Joice Dos Santos de Jesus Gabriel Jeferson Rodríguez Machado Hatilla Dos Santos Silva Helena Mariana Pitangueira Teixeira Juliana Lopes Rodrigues Camila Alexandrina Viana de Figueiredo Ryan S Costa Fabio Hecht Antonio Carlos Bianco Maria da Conceição Rodrigues Gonçalves Helton Estrela Ramos

Published in: The Journal of clinical endocrinology and metabolism (2022)

Here we provide evidence for a protective role played by Thr92Ala-DIO2 heterozygosity in patients with COVID-19. This protective effect follows an inheritance model known as overdominance, in which the phenotype of the heterozygote lies outside the phenotypical range of both homozygous.

Keyphrases

coronavirus disease
sars cov
cardiovascular events
mitochondrial dna
risk factors
respiratory syndrome coronavirus
gene expression
dna methylation
cardiovascular disease
copy number
genome wide