Independent mapping methods reveal rotational activation near pulmonary veins where atrial fibrillation terminates before pulmonary vein isolation.
Rachita NavaraGeorge LeefFatemah ShenasaChristopher KowalewskiAlbert J RogersGabriela MecklerJunaid A B ZamanTina BaykanerShirley ParkMintu P TurakhiaPaul ZeiMohan ViswanathanPaul J WangSanjiv M NarayanPublished in: Journal of cardiovascular electrophysiology (2018)
PV antral regions where ablation terminated AF before PVI exhibited rotational and focal activation by two independent mapping methods. These data provide an alternative mechanism for the success of PVI, and may explain AF termination before PVI or lack of arrhythmias despite PV reconnection. Mapping such sites may enable targeted PV lesion sets and improved freedom from AF.
Keyphrases
- atrial fibrillation
- catheter ablation
- high resolution
- oral anticoagulants
- left atrial
- high density
- left atrial appendage
- direct oral anticoagulants
- heart failure
- percutaneous coronary intervention
- genome wide
- coronary artery disease
- gene expression
- big data
- dna methylation
- left ventricular
- mitral valve
- radiofrequency ablation