Liquid biopsy with multiplex ligation-dependent probe amplification targeting cell-free tumor DNA in cerebrospinal fluid from patients with adult diffuse glioma.
Ryosuke OtsujiYutaka FujiokaNobuhiro HataDaisuke KugaYuhei SangatsudaKosuke TakigawaYusuke FunakoshiAki SakoHidetaka YamamotoAkira NakamizoMasahiro MizoguchiKoji YoshimotoPublished in: Neuro-oncology advances (2022)
Thus, our results demonstrate that copy number analysis can be successfully performed by MLPA of cfDNA extracted from the CSF of patients with diffuse glioma.