Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch.

Annelisa M CornelEster DunnebachDamon A HofmanSanjukta DasSatyaki SenguptaFemke van den HamJudith WienkeJosephine G M StrijkerDenise A M H van den BeemtAnke H W EssingBianca KoopmansSem A G EngelsVania Lo PrestiCelina S SzantoRani E GeorgeJan J MolenaarSebastiaan van HeeschMiranda P DierselhuisS Nierkens

Published in: Journal for immunotherapy of cancer (2022)

This study indicates the potential of combining (immuno)therapy with HDACi to enhance both T cell-driven and NKcell-driven immune responses in patients with HR-NBL.

Keyphrases

nk cells
immune response
single cell
dna methylation
gene expression
cell therapy
toll like receptor
dendritic cells
stem cells
human health
risk assessment
inflammatory response