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Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch.

Annelisa M CornelEster DunnebachDamon A HofmanSanjukta DasSatyaki SenguptaFemke van den HamJudith WienkeJosephine G M StrijkerDenise A M H van den BeemtAnke H W EssingBianca KoopmansSem A G EngelsVania Lo PrestiCelina S SzantoRani E GeorgeJan J MolenaarSebastiaan van HeeschMiranda P DierselhuisS Nierkens
Published in: Journal for immunotherapy of cancer (2022)
This study indicates the potential of combining (immuno)therapy with HDACi to enhance both T cell-driven and NKcell-driven immune responses in patients with HR-NBL.
Keyphrases
  • nk cells
  • immune response
  • single cell
  • dna methylation
  • gene expression
  • cell therapy
  • toll like receptor
  • dendritic cells
  • stem cells
  • human health
  • risk assessment
  • inflammatory response