Effect of drug treatment changes and seizure outcomes on depression and suicidality in adults with drug-resistant focal epilepsy.

Almost 1 in 5 adults with drug resistant focal epilepsy who screen negative for depression become positive when re-assessed 6 months after a treatment change. 6.1% who screen initially negative for passive suicidal ideation become positive at re-assessment 6 months later. These changes in screening status are independent of type of ASM introduced or seizure outcomes, but correlate with psychiatric status at baseline.