A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma.

Haitham AlRabiahAdnan A KadiHaya I AljoharMohamed W AttwaNasser S Al-ShakliahSabry M Attia Gamal A E Mostafa

Published in: Drug design, development and therapy (2020)

This method was selectively sensitive and exhibited no matrix effect, with an acceptable accuracy and precision according to the FDA guidelines. The developed method could be efficiently used for pharmacokinetic studies of dovitinib.

Keyphrases

ms ms
mass spectrometry
clinical practice
high performance liquid chromatography
case control
solid phase extraction
tandem mass spectrometry