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Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.

Yalan LeiJin XuMingming XiaoDi WuHe XuJing YangXiaoqi MaoHaoqi PanXian-Jun YuXianjun Yu
Published in: British journal of cancer (2024)
Pirfenidone may alter the pancreatic milieu and alleviate fibrosis through the regulation of tumour-stroma interactions via the TGM2/NF-kB/PDGFB signalling pathway, suggesting potential therapeutic benefits in PDAC management.
Keyphrases
  • idiopathic pulmonary fibrosis
  • pulmonary fibrosis
  • signaling pathway
  • lps induced
  • oxidative stress
  • liver fibrosis
  • pi k akt
  • inflammatory response
  • toll like receptor