The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models In Vivo Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ.
Yuan YangHoward H YangBinwu TangAlex Man Lai WuKathleen C FlandersNellie MoshkovichDouglas S WeinbergMichael A WelshJia WengHumberto J OchoaTiffany Y HuMichelle A HerrmannJinqiu ChenElijah F EdmondsonR Mark SimpsonFang LiuHuaitian LiuMaxwell P LeeLalage M WakefieldPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Contrary to dogma, tumor-suppressive responses to TGFβ are retained in some advanced metastatic tumors. Safe deployment of TGFβ antagonists in the clinic will require good predictive biomarkers.