Development and Preclinical Evaluation of 99mTc- and 186Re-Labeled NOTA and NODAGA Bioconjugates Demonstrating Matched Pair Targeting of GRPR-Expressing Tumors.

George MakrisRajendra P BandariMarina KuchukSilvia S JurissonCharles J SmithHeather M Hennkens

Published in: Molecular imaging and biology (2020)

[99mTc]Tc-2 shows promise for further development as a GRPR-imaging agent. [186Re]Re-2 demonstrated very similar in vivo behavior to [99mTc]Tc-2, and further studies are therefore justified to explore the theranostic potential of our approach for targeting of GRPR-positive cancers.

Keyphrases

cancer therapy
photodynamic therapy
fluorescence imaging
stem cells
big data
machine learning
bone marrow
mesenchymal stem cells
climate change
deep learning
artificial intelligence