Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid - a CF3O-containing analogue of natural lipophilic amino acids.
Ivan S KondratovIvan G LogvinenkoNataliya A TolmachovaRoman N MorevMaria A KliachynaFlorian ClausenConstantin G DaniliucGünter HaufePublished in: Organic & biomolecular chemistry (2018)
2-Amino-2-(trifluoromethoxy)butanoic acid (O-trifluoromethyl homoserine) was synthesized as a racemate and in both enantiomeric forms. The measured pKa and log D values establish the compound as a promising analogue of natural aliphatic amino acids.