Simultaneous activation of impaired autophagy and the mammalian target of rapamycin pathway in oral squamous cell carcinoma.

Xubin YinLiang HuXiaoyu FengHongyun WangChunmei ZhangHao WangSonglin Wang

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)

The study suggests that autophagy is impaired in patients with OSCC and impaired autophagy and the mTOR pathway are simultaneously activated in OSCC cells.

Keyphrases

endoplasmic reticulum stress
cell death
induced apoptosis
signaling pathway
oxidative stress
cell cycle arrest
cell proliferation