BNIP3 as a new tool to promote healthy brain aging.

Kit NeikirkAndrea G MarshallMonica M Santisteban Antentor O Hinton

Published in: Aging cell (2023)

The article "Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in Drosophila" reveals BCL2-interacting protein 3 as a therapeutic target to counteract brain aging and prolong overall organismal health with age. In this spotlight, we consider the roles of BNIP3, a mitochondrial outer membrane protein, in the adult nervous system, including its induction of mitophagy and prevention of dysfunctional mitochondria in the aged brain. Implications for other tissue types to reduce the burden of aging are further considered.

Keyphrases

resting state
white matter
cerebral ischemia
functional connectivity
oxidative stress
mental health
nlrp inflammasome
risk factors
blood brain barrier
multiple sclerosis
small molecule
risk assessment
young adults
reactive oxygen species
health promotion
human health