Cigarette smoke extract stimulates bronchial epithelial cells to undergo a SUMOylation turnover.
Haifeng ZhouLei ZhangYang LiGuorao WuHe ZhuHuilan ZhangJia-Kun SuLei GuoQing ZhouFei XiongQilin YuPing YangShu ZhangJibao CaiCong-Yi WangPublished in: BMC pulmonary medicine (2020)
Our data provide a protein SUMOylation profile for better understanding of the mechanisms underlying COPD and support that smoking induces oxidative stress in HBEs, which may predispose to the development of COPD in clinical settings.