Gsα Regulates Macrophage Foam Cell Formation During Atherosclerosis.

Chang Ma Yihui LiMi TianQiming DengXiaoteng QinHanlin LuJiangang GaoMin ChenLee S Weinstein Teng-Fei ZhengPeili BuJianmin Yang Yun Zhang Cheng Zhang Wencheng Zhang

Published in: Circulation research (2024)

Gsα activation is enhanced during atherosclerotic progression and increases lipid uptake and foam cell formation. The genetic or chemical inactivation of Gsα inhibit the development of atherosclerosis in mice, suggesting that drugs targeting Gsα may be useful in the treatment of atherosclerosis.

Keyphrases

cardiovascular disease
single cell
cell therapy
adipose tissue
stem cells
gene expression
skeletal muscle
high fat diet induced
copy number
bone marrow
combination therapy
replacement therapy