Synergistic Effect of Lenvatinib and Chemotherapy in Hepatocellular Carcinoma Using Preclinical Models.

Mingxun WangXinfei YaoZhiyuan BoJiuyi ZhengHaitao YuXiaozai XieZixia LinYi WangGang ChenLijun Wu

Published in: Journal of hepatocellular carcinoma (2023)

Lenvatinib combined with FOLFOX had a synergistic antitumor effect in HCC PDX and XDOTS models by inhibiting the phosphorylation of VEGFR, RET, and ERK.

Keyphrases

signaling pathway
cell proliferation
pi k akt
vascular endothelial growth factor
cell therapy
stem cells
squamous cell carcinoma
radiation therapy
drug delivery