Phenylalanine intercalation parameters for liquid-disordered phase domains - a membrane model study.

Phe appeared to discriminate between DPPE and DPPC packing, and use two modes of intercalation. The area of A Phe 33 ± 2 Å2 is consistent with a Phe monomer intercalating into membrane by inserting the phenyl ring nearly normal to the membrane surface. This mode has been found to operate in DPPE membranes. For DPPC membranes however, the value of A Phe = 48 ± 3 Å2 suggests that, from saline, Phe tends to intercalate as a larger species plausibly dragging along a counterion, Na+, in a Na+(Phe) complex.