A two-stage genome-wide association study of radiation-induced acute toxicity in head and neck cancer.

Elnaz NaderiAnne Petra Gerarda CrijnsRoel Johannes Henricus Marinus SteenbakkersJohanna Geertruida Maria van den HoekHendrika Marike BoezenBehrooz Ziad AlizadehJohannes Albertus Langendijk

Published in: Journal of translational medicine (2021)

This GWAS suggested novel SNPs for patient-rated acute xerostomia in HNC patients. If validated, these SNPs and their related functional pathways could lead to a predictive assay to identify sensitive patients to radiation, which may eventually allow a more individualized RT treatment.

Keyphrases

genome wide
radiation induced
end stage renal disease
ejection fraction
newly diagnosed
liver failure
prognostic factors
radiation therapy
high throughput
oxidative stress
drug induced
case report
hepatitis b virus