Long-lasting visceral hypersensitivity in a model of DSS-induced colitis in rats.

Sergio López-EstévezJosep Manuel López-TorrellardonaMarc PareraVicente Martínez

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2022)

DSS-induced colitis in rats is associated to the generation of a long-lasting state of visceral (colonic) hypersensitivity, despite clinical colitis resolution. This model reproduces the changes in intestinal sensitivity characteristics of inflammatory and functional gastrointestinal disorders in humans and can be used in the characterization of new pharmacological treatments against visceral pain.

Keyphrases

insulin resistance
chronic pain
drug induced
ulcerative colitis
pain management
metabolic syndrome
single molecule
spinal cord
postoperative pain