Shared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes.

Wanchen Ning Yihong Ma Simin Li Xin Wang Hongying Pan Chen-Xuan Wei Shaochuan Zhang Dongying Bai Xiangqiong Liu Yupei Deng Aneesha Acharya Georgios Pelekos Vuk Savković Hanluo Li Sebastian Gaus Rainer Haak Gerhard Schmalz Dirk Ziebolz Yanbo Ma Yuzhen Xu

Published in: Computational and mathematical methods in medicine (2021)

Exploration of available transcriptomic datasets revealed core crosstalk genes (RASGRP2, VAMP7, SNX3, HMGB1, SUMO1, SEC61G, PSMB2, SELPLG, and FIBP) and significant pathways (bacterial invasion of epithelial cells, platelet activation, and MAPK signaling) as top candidate molecular linkage mechanisms between atherosclerosis and periodontitis.

Keyphrases

peripheral blood
single cell
rna seq
genome wide
cardiovascular disease
signaling pathway
cell migration
oxidative stress
pi k akt
hiv testing
dna methylation
type diabetes
gene expression
genome wide identification
hepatitis c virus
human immunodeficiency virus
genome wide analysis