Development, wiring and function of dopamine neuron subtypes.
Oxana GarritsenEljo Y van BattumLaurens M GrossouwRonald Jeroen PasterkampPublished in: Nature reviews. Neuroscience (2023)
The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and recent work has begun to unveil how these neuronal subtypes develop and organize into functional brain structures. This progress is important for further understanding the disparate physiological functions of mDA neurons and their selective vulnerability in disease, and will ultimately accelerate therapy development. This Review discusses recent advances in our understanding of molecularly defined mDA neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.
Keyphrases
- breast cancer cells
- cell cycle arrest
- resting state
- white matter
- climate change
- cerebral ischemia
- spinal cord
- metabolic syndrome
- high resolution
- cell death
- multiple sclerosis
- stem cells
- functional connectivity
- spinal cord injury
- mass spectrometry
- subarachnoid hemorrhage
- blood brain barrier
- prefrontal cortex
- replacement therapy