Macrophage-derived progranulin promotes allergen-induced airway inflammation.
Jun-Pyo ChoiSo Young ParkKeun-Ai MoonEun Hee HaYeon Duk WooDoo Hyun ChungHyouk-Soo KwonTae Bum KimHae-Sim ParkHee-Bom MoonHeung-Woo ParkYou Sook ChoPublished in: Allergy (2020)
The presence of macrophage-derived PGRN in airways in the early sensitization period may be critical for mounting a Th2 immune response and for following an allergic airway inflammation pathway via induction of type 2 cytokine production in NKT and airway epithelial cells.