Chronic treatment of (R)-α-lipoic acid reduces blood glucose and lipid levels in high-fat diet and low-dose streptozotocin-induced metabolic syndrome and type 2 diabetes in Sprague-Dawley rats.
Hardik GhelaniValentina Razmovski-NaumovskiSrinivas NammiPublished in: Pharmacology research & perspectives (2017)
(R)- α -lipoic acid (ALA), an essential cofactor in mitochondrial respiration and a potential antioxidant, possesses a wide array of metabolic benefits including anti-obesity, glucose lowering, insulin-sensitizing, and lipid-lowering effects. In this study, the curative effects of ALA (100 mg/kg) on a spectrum of conditions related to metabolic syndrome and type 2 diabetes (T2D) were investigated in a high-fat diet (HFD)-fed and low-dose streptozotocin (STZ)-induced rat model of metabolic syndrome and T2D. The marked rise in the levels of glucose, triglycerides, total-cholesterol, LDL-cholesterol, and VLDL-cholesterol in the blood of HFD-fed and low-dose STZ-injected rats were significantly reduced by ALA treatment. Furthermore, ALA treatment significantly increased the serum HDL-cholesterol levels and tended to inhibit diabetes-induced weight reduction. Mathematical computational analysis revealed that ALA also significantly improved insulin sensitivity and reduced the risk of atherosclerotic lesions and coronary atherogenesis. This study provides scientific evidence to substantiate the use of ALA to mitigate the glucose and lipid abnormality in metabolic syndrome and T2D.
Keyphrases
- high fat diet
- insulin resistance
- metabolic syndrome
- type diabetes
- diabetic rats
- blood glucose
- low dose
- glycemic control
- adipose tissue
- oxidative stress
- low density lipoprotein
- skeletal muscle
- high fat diet induced
- cardiovascular disease
- high glucose
- uric acid
- coronary artery disease
- physical activity
- combination therapy
- weight gain
- heart failure
- body mass index
- risk assessment
- endothelial cells
- blood pressure
- anti inflammatory
- high speed
- atrial fibrillation
- aortic valve
- prognostic factors
- smoking cessation
- replacement therapy