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Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia.
Han Xie
Yanyi Jiang
Yufei Xiang
Baoming Wu
Jiajia Zhao
Ruixiang Huang
Mengting Wang
Yunlong Wang
Jun Liu
Dejun Wu
Dasheng Tian
Erbao Bian
Published in:
Neuro-oncology (2024)
Our research reveals that the epigenetic-mediated interaction of GBM cells with TAM drives the MES transition of GBM and provides a novel therapeutic avenue for patients with MES GBM.
Keyphrases
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induced apoptosis
cell cycle arrest
signaling pathway
stem cells
dna methylation
gene expression
inflammatory response
bone marrow
transcription factor
neuropathic pain
endoplasmic reticulum stress
binding protein
oxidative stress
cell death
spinal cord