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Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma.

Alberto BroniscerSujuan JiaBelinda MandrellDima HamidehJie HuangArzu Onar-ThomasAmar GajjarSusana C RaimondiRuth G TatevossianClinton F Stewart
Published in: Pediatric blood & cancer (2018)
This drug combination was poorly tolerated and its activity was minimal. We do not recommend further testing of this combination in children.
Keyphrases
  • high grade
  • young adults
  • low grade
  • multiple sclerosis
  • emergency department
  • adverse drug
  • drug induced