The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.
Qiang YuTong LiuSainan LiJiao FengLiwei WuWenwen WangKan ChenYujing XiaPeiqin NiuLing XuFan WangWeiqi DaiYingqun ZhouChuanyong GuoPublished in: Mediators of inflammation (2018)
L-THP could decrease serum liver enzymes and pathological damage by reducing the release of inflammatory factors like IL-6 and TNF-α. The results of Western Blot and PCR indicated that L-THP could ameliorate liver cell apoptosis and autophagy. L-THP could suppress T lymphocyte proliferation and the production of TNF-α and IL-6 induced by ConA in a dose-dependent manner in vitro. Additionally, the protective functions of L-THP depended on downregulating TRAF6/JNK signaling. Conclusion. The present study indicated that L-THP attenuated acute liver injury in ConA-induced autoimmune hepatitis by inhibiting apoptosis and autophagy via the TRAF6/JNK pathway.
Keyphrases
- signaling pathway
- drug induced
- liver injury
- cell death
- oxidative stress
- induced apoptosis
- endoplasmic reticulum stress
- cell cycle arrest
- pi k akt
- rheumatoid arthritis
- diabetic rats
- multiple sclerosis
- cell proliferation
- south africa
- liver failure
- endothelial cells
- high glucose
- respiratory failure
- hepatitis b virus
- extracorporeal membrane oxygenation